PENGARUH PAPARAN ASAP OBAT NYAMUK BAKAR TERHADAP KADAR ESTROGEN DAN KUALITAS SPERMATOZOA PADA MENCIT (Mus musculus)

Eka Desnita; Almahdy Almahdy; Yufri Aldi; Fatma Sri Wahyuni; Dachriyanus; Rama Feriska Putra

doi:10.51352/jim.v12i1.989

Eka Desnita Fakultas Farmasi, Universitas Andalas, Padang & Prodi Farmasi Klinis, Fakultas Ilmu Kesehatan, Universitas Baiturrahmah, Padang
Almahdy Almahdy Fakultas Farmasi, Universitas Andalas, Padang
Yufri Aldi Fakultas Farmasi, Universitas Andalas, Padang
Fatma Sri Wahyuni Fakultas Farmasi, Universitas Andalas, Padang
Dachriyanus Fakultas Farmasi, Universitas Andalas, Padang
Rama Feriska Putra Prodi Farmasi Klinis, Fakultas Ilmu Kesehatan, Universitas Baiturrahmah, Padang

DOI: https://doi.org/10.51352/jim.v12i1.989

Abstract

Mosquito coils containing synthetic pyrethroids are widely used in households and may pose reproductive health risks due to inhalation of combustion smoke. This study aimed to evaluate the effects of mosquito coil smoke exposure on sperm quality and serum estrogen levels. An experimental study was conducted using Mus musculus divided into control and exposure groups. The observed parameters included sperm concentration, sperm morphology, and serum estrogen levels, which were statistically analyzed to determine differences between groups. The results demonstrated that mosquito coil smoke exposure significantly decreased sperm concentration and increased abnormal sperm morphology compared to the control group (p < 0.05). A decreasing trend in serum estrogen levels was observed in the exposure group; however, the difference was not statistically significant (p > 0.05). In conclusion, exposure to mosquito coil smoke containing synthetic pyrethroids may impair sperm quality and influence hormonal regulation. These findings suggest a potential risk of reproductive dysfunction associated with chronic household insecticide exposure.