UJI ANTI INFLAMASI EKTRAK KOMBINASI TERIPANG PASIR(HOLOTHURIA SCABRA) DAN DAUN KERSEN (MUNTINGIACALABURAL.) PADA TIKUS (RATTUS NORVEGICUS)

Abstract

Sea cucumber (Holothuria scabra) and Kersen leaf (Muntingia calabura L.) are used as traditional medicines that have anti-inflammatory activity. This study aims to determine the anti-inflammatory activity of a combination of ethanol extract of sea cucumber sand and Kersen leaves on the decrease of edema in the feet of rats that have been induced with 1% carrageenan. The rats were then divided into 5 groups and each group consisted of 3 rats. Group 1 as positive control, group 2 as negative control, group 3 as extract combination 1: 1 (200 mg / kg body weight: 200 mg / kg body weight), group 4 as extract combination 1: 2 (200 mg / kg body weight: 400 mg / kg body weight) ), group 5 as extract combination 2: 1 (400 mg / kgBB: 200 mg / kgBB), and each group is given orally. At 2: 1 EK has the same anti-inflammatory effect as positive control with% DAI, which is 4.84%. Whereas at EK 1: 2 with% DAI 4.24% and EK 1: 1 with% DAI 1.81%.