OPTIMASI FORMULA SUPOSITORIA PARACETAMOL KOMBINASI BASIS LEMAK COKLAT (Theobroma cacao L.) DAN LEMAK TENGKAWANG (Shorea mecistopteryx Ridl.) DENGAN METODE SIMPLEX LATTICE DESIGN (SLD)

Abstract

Suppositories, are solid forms of medication intended for rectal, vaginal, or urethral administration. Cocoa butter (Theobroma cacao L.) is a widely used base in suppository formulations. However, Tengkawang fat (Shorea mecistopteryx Ridl.) shows potential as an alternative substitute due to its similar characteristics to cocoa butter and its superior stability, as it does not undergo significant polymorphic changes after heating, cooling, and storage. This study aimed to find optimal formulation of a paracetamol suppository using a combination of Tengkawang fat and cocoa butter bases to achieve ideal physical stability. An experimental research method was employed, utilizing a Simplex Lattice Design (SLD) to optimize the base ratios. The formula physical content was then analyzed using Design-Expert® 13. The experiment found that configuration consisted of 36.79% Tengkawang fat and 63.21% cocoa butter had optimum results that significantly influences the physical characteristics and stability of the paracetamol suppository, ensuring it meets the physical requirements of a good suppository.